Serveur d'exploration Chloroquine

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Deciphering the Role Played by Autophagy in Leishmania Infection

Identifieur interne : 000906 ( Main/Exploration ); précédent : 000905; suivant : 000907

Deciphering the Role Played by Autophagy in Leishmania Infection

Auteurs : Patricia Sampaio Tavares Veras [Brésil] ; Juliana Perrone Bezerra De Menezes [Brésil] ; Beatriz Rocha Sim Es Dias [Brésil]

Source :

RBID : PMC:6838865

Abstract

In recent decades, studies have shown that, depending on parasite species and host background, autophagy can either favor infection or promote parasite clearance. To date, relatively few studies have attempted to assess the role played by autophagy in Leishmania infection. While it has been consistently shown that Leishmania spp. induce autophagy in a variety of cell types, published results regarding the effects of autophagic modulation on Leishmania survival are contradictory. The present review, after a short overview of the general aspects of autophagy, aims to summarize the current body of knowledge surrounding how Leishmania spp. adaptively interact with macrophages, the host cells mainly involved in controlling leishmaniasis. We then explore the scarce studies that have investigated interactions between these parasite species and the autophagic pathway, and finally present a critical perspective on how autophagy influences infection outcome.


Url:
DOI: 10.3389/fimmu.2019.02523
PubMed: 31736955
PubMed Central: 6838865


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Kaushik, S" uniqKey="Kaushik S">S Kaushik</name>
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<author>
<name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
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<author>
<name sortKey="Xiang, Y" uniqKey="Xiang Y">Y Xiang</name>
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<author>
<name sortKey="Novak, I" uniqKey="Novak I">I Novak</name>
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<author>
<name sortKey="Komatsu, M" uniqKey="Komatsu M">M Komatsu</name>
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<name sortKey="Saito, T" uniqKey="Saito T">T Saito</name>
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<author>
<name sortKey="Kuma, A" uniqKey="Kuma A">A Kuma</name>
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<author>
<name sortKey="Sugiura, Y" uniqKey="Sugiura Y">Y Sugiura</name>
</author>
<author>
<name sortKey="Ichimura, Y" uniqKey="Ichimura Y">Y Ichimura</name>
</author>
<author>
<name sortKey="Obata, M" uniqKey="Obata M">M Obata</name>
</author>
<author>
<name sortKey="Kitamura, H" uniqKey="Kitamura H">H Kitamura</name>
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<country>
<li>Brésil</li>
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<name sortKey="Veras, Patricia Sampaio Tavares" sort="Veras, Patricia Sampaio Tavares" uniqKey="Veras P" first="Patricia Sampaio Tavares" last="Veras">Patricia Sampaio Tavares Veras</name>
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